GLP1-S

Overview

GLP1-S is a synthetic analog of glucagon-like peptide-1 (GLP-1), a naturally occurring hormone produced in the intestines. Its molecular formula is C₁₈₇H₂₉₁N₄₅O₅₉, with a molecular weight of 4,113.64 g/mol (CAS 910463-68-2). First described in the scientific literature in 2007, it is classified as a GLP-1 receptor agonist — a synthetic analog structurally derived from the native GLP-1 peptide.

What distinguishes GLP1-S from the native hormone is a series of structural modifications. A key change is the substitution of alanine at position 8 with alpha-aminoisobutyric acid (Aib), a substitution that distinguishes it from the native GLP-1 sequence. Additionally, a C-18 fatty diacid chain is attached via a linker at position 26, a modification shared with other long-acting peptide analogs. These chemical changes distinguish GLP1-S structurally from the native 30-amino-acid GLP-1 peptide, which breaks down within minutes. In its research-grade form, GLP1-S appears as a white lyophilized powder that is soluble in water.

This product is strictly for research purposes only. Not approved for human or animal use.

PubChem Reference: View compound profile on NIH PubChem