Cagrilintide

Overview

Cagrilintide is a synthetic analog of amylin, a 37-amino acid peptide hormone that is naturally co-secreted with insulin from pancreatic beta cells. Cagrilintide was designed as a long-acting version of the native amylin molecule, with specific amino acid substitutions and an acylation — the attachment of a fatty acid chain — that slows its clearance from solution.

The compound has the molecular formula C₁₉₄H₃₁₂N₅₄O₅₉S₂, a molecular weight of approximately 4,409 g/mol, and a CAS number of 1415456-99-3. It is classified as an acylated amylin receptor agonist. Cagrilintide is supplied as a white lyophilized powder that is soluble in water. The key structural modification is the fatty acid sidechain, which enables albumin binding and extends the molecule’s half-life substantially compared to native amylin, which breaks down within minutes in solution.

This product is strictly for research purposes only. Not approved for human or animal use.

PubChem Reference: View compound profile on NIH PubChem