Thymosin Beta-4

Overview

Thymosin Beta-4 is a 43-amino-acid peptide encoded by the TMSB4X gene and the most abundant member of the beta-thymosin family. It has the molecular formula C₂₁₂H₃₅₀N₅₆O₇₈S, a molecular weight of approximately 4963 g/mol, and CAS number 77591-33-4. The peptide was first isolated from calf thymus tissue in 1981 and has since been studied as a principal G-actin–sequestering protein in mammalian cells.

Structurally, Thymosin Beta-4 carries an N-terminal acetyl group on its serine residue. Its full sequence is Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser. The central LKKTETQ motif is the defining actin-binding domain and has been the focus of in-vitro biochemical characterization.

This product is strictly for research purposes only. Not approved for human or animal use.

PubChem Reference: View compound profile on NIH PubChem

Key Characteristics

MOLECULAR PROFILE

Formula: C₂₁₂H₃₅₀N₅₆O₇₈S

Weight: 4963 g/mol

CAS: 77591-33-4

Structure: 43 amino acid acetylated peptide

PHYSICAL PROPERTIES

Form: White to off-white lyophilized powder

Solubility: Soluble in water

Purity: ≥98% (HPLC)

Storage: Keep refrigerated 36‑46 °F (2‑8 °C)

Weight	0.08 lbs
Dimensions	0.87 × 1.18 × 0.87 in
Size	5mg, 10mg